May 16, 2022

What is Pepsin? Similarities between Pepsin and Pepsinogen

Pepsin also has other industrial applications, including digestion of antibodies, preparation of collagen for cosmetic purposes, assessment of the digestibility of proteins in food chemistry, and more.

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What is pepsinogen?

Pepsinogen is a progenzyme or zymogen, which is an inactive precursor of pepsin. It is secreted by gastric main cells. The primary structure of pepsinogen contains an additional 44 amino acids, which have to be cleaved to become the active form of the enzyme. Hydrochloric acid (HCl) from gastric juice is responsible for this leak. Here, the progenzyme is exposed to the acidic environment created by HCl. Then, the excess amino acids shut down in an autocatalytic fashion.

  1. Gastric lumen, 1. pepsinogen, 2. pepsin, b. Mucus-bicarbonate barrier, 3. Mucus, c. Epithelial tight junctions, d. Surface Mucus Sales, e. Interstinal Fluid, f. Capillary.
  • Pepsin and pepsinogen are two types of protein-digestive enzymes that are present in the stomach.
  • They are responsible for the breakdown of proteins into small chains of amino acids that can be easily absorbed by the small intestine.
  • In addition, they are one of the three principle principles secreted by the digestive system. 

Furthermore, both are aspartic proteases, in which the active site contains an aspartate.

Both perform their functions below pH 5.

Difference between Pepsin and Pepsinogen

Definition

Pepsin refers to the main digestive enzyme in the stomach, which breaks down proteins into a polypeptide, while pepsinogen refers to a substance that is secreted from the stomach wall and converted to the enzyme pepsin by gastric acid. 

The activity

Furthermore, another difference between pepsin and pepsinogen is that pepsin is the active protease whereas pepsinogen is the pro-enzyme of pepsin.

Role

Pepsin digests proteins in short chains of amino acids while pepsinogen is activated in pepsin by HCl present in gastric juice. 

The main difference – Idioms vs Idioms

Both idioms and phrases refer to a small group of words that express a concept. The main difference between idioms and phrases is that idioms have a specific meaning that is unrelated to the meaning represented by their individual words. 

What is a phrase?

An idiom is a group word with an established meaning that is unrelated to the individual meaning of the words. The Oxford Dictionary establishes idioms as “the use of a set of words, meaning that a person has no meaning in different words.” It is important to note that an idiom is also a phrase.

Here, this phrase does not really mean that cats and dogs are falling from the sky. It signifies heavy rain.

Given below are some English language idioms.

A storm in a tea bag – great excitement about a trivial thing

To pull someone’s leg – to trick them into saying something untrue

et an ax – lose a job

Think on your feet — work quickly to make rapid changes and make fast decisions.

They can also be used as simple phrases. The following sentence pairs describe how the meaning of the phrases changes depending on the context.

Example 1

Finally, at the end of the lecture, he saw the light and realized how foolish his first impression was.

He looked at the lighthouse.

Example 2

The company was losing money; Many employees received an ax.

He got the ax and went out to investigate the strange noise.

What is a phrase?

A phrase is a group of words standing together as a conceptual unit. In linguistic analysis, it serves as a component of the syntax of a sentence. However, in general usage, people use a phrase to refer to expressions with particular idiomatic meaning. Some examples of such phrases include all rights reserved, suddenly, so to speak, lights, camera, action, falling in line, etc. These are different from idioms because they are used as parts of sentences and The standard way is to express a concept.

Meaning of phrase

The meanings of individual words do not indicate the meaning of the idiom.

The meanings of individual words contribute to the entire meaning of the phrase.

Mutually

Idioms are phrases.

Phrases can have idiomatic meanings.

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The Conclusion

Pepsin is the main form of protein digestive enzyme in the stomach. It is responsible for the digestion of proteins into small chains of amino acids that can be absorbed by the small intestine. In comparison, pepsinogen in the progenum of pepsin and it is a secreted form of pepsin by the stomach. It is activated by cleaning the excess residue of 44 amino acids by the action of HCl in gastric juice.

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